Next-Generation Nutraceutical Ingredients for Cellular Health & Anti-Aging Formulas
GMP-audited production, full COA documentation, global bulk supply
New Products Overview
New Products is Purecium's curated line of next-generation bulk ingredients for dietary supplement manufacturers, formulators and brands targeting cellular health, healthy aging, cognitive performance and longevity positioning. The range spans NAD+ precursors such as NMN and nicotinamide riboside, polyphenol metabolites such as urolithin A, the autophagy-supporting polyamine spermidine, the flavonoid fisetin, and the nootropic phospholipid precursor citicoline. Every ingredient is supplied as a single-entity raw material with a defined specification, documented identity and batch traceability for capsule, tablet, powder, stick-pack and beverage applications.
This B2B guide explains how each product is sourced, identified, manufactured, tested and shipped, and it is written for procurement, quality and R&D teams who need clear technical and commercial answers before they commit to a bulk order. Typical grades are 98-99% assay by HPLC, with food-grade or pharmaceutical-grade specifications depending on the product and target market.
Source & Ingredient Identity
The New Products line is built on six core molecules, each with an unambiguous chemical identity that is verified on every batch through reference-standard chromatography. A synonym of each compound is given with the CAS registry number, molecular formula and molecular weight so that buyers can cross-check technical data sheets and import documentation against independent references such as PubChem.
NMN (β-Nicotinamide Mononucleotide) - CAS 1094-61-7; molecular formula C11H15N2O8P; molecular weight 334.22 g/mol. Produced by enzymatic synthesis from D-ribose and nicotinamide, supplied as a white crystalline powder.
NR HCL (Nicotinamide Riboside Chloride) - CAS 23111-00-4; molecular formula C11H15ClN2O5; molecular weight 290.70 g/mol. A chloride salt form of nicotinamide riboside (cation CAS 1341-23-7), supplied as a free-flowing crystalline powder with 98% minimum assay.
Urolithin A - CAS 1143-70-0; molecular formula C13H8O4; molecular weight 228.20 g/mol. A gut-microbiota metabolite of ellagitannins from pomegranate and berries, now produced by controlled fermentation and supplied at 98% minimum assay. Urolithin B (C13H8O3, 212.20 g/mol) is available on request.
Spermidine - CAS 124-20-9; molecular formula C7H19N3; molecular weight 145.25 g/mol. Supplied as spermidine trihydrochloride (assay 98% by HPLC) or as a naturally occurring wheat-germ extract standardized to spermidine content.
Fisetin - CAS 528-48-3; molecular formula C15H10O6; molecular weight 286.24 g/mol. A flavonoid found in strawberry and apple, supplied as a 98% HPLC-purified powder from natural extraction.
Citicoline (CDP-Choline) - CAS 987-78-0; molecular formula C14H26N4O11P2; molecular weight 488.33 g/mol. Supplied as citicoline free form or citicoline sodium, with assay of 98-102% and specified impurity control per batch.
Key Characteristics of New-Generation Ingredients
As a group, these molecules share the characteristics that formulation teams look for in advanced nutrition products: defined single-molecule identity, good stability in dry formats, low inclusion rates, and a growing body of peer-reviewed research on their mechanisms. NMN and NR are direct precursors in the NAD+ salvage and recycling pathway, which supports cellular energy metabolism; urolithin A is studied for its role in mitophagy; spermidine is associated with autophagy and cellular renewal; fisetin behaves as a flavonoid antioxidant; and citicoline supports phospholipid synthesis in neural tissue.
Physical properties matter for manufacturing. NMN, NR HCL and spermidine trihydrochloride are crystalline powders with good flowability and high water solubility; urolithin A and fisetin are fine, low-solubility powders suited to encapsulation with a suitable carrier; citicoline is freely soluble and can be tableted directly. All are manufactured to minimize residual solvents and heavy metals so that they fit clean-label finished-product claims.
New Products Manufacturing
Purecium produces and sources these ingredients under controlled conditions: enzymatic and chemical synthesis for NMN and NR HCL, microbial fermentation for urolithin A, natural extraction for fisetin and wheat-germ spermidine, and synthesis for citicoline. Every route is selected to deliver consistent assay, low impurity profile and batch-to-batch reproducibility at commercial scale.
Manufacturing steps are documented from raw material intake through reaction or extraction, isolation, purification, crystallization, drying, milling and final blending. Critical process parameters are recorded, and each production lot is quarantined until quality control release. Standard packing is 25 kg per drum with food-grade inner liners, and smaller laboratory or stability batches can be arranged for evaluation.
Applications of New Products
The primary application categories are dietary supplements for cellular energy and healthy aging (NMN, NR, urolithin A), longevity and autophagy support (spermidine, fisetin), and cognitive or brain-health formulas (citicoline, fisetin). Published clinical studies suggest these ingredients influence NAD+ metabolism, mitochondrial function and cellular recycling pathways, and the NIH Office of Dietary Supplements recognizes nicotinamide and related pyridine nucleosides as forms of vitamin B3 relevant to NAD+ nutrition.
Formulators use NMN and NR in morning energy or anti-aging capsules, urolithin A in muscle-health and longevity blends, spermidine in cellular-renewal formulas, fisetin in antioxidant and cognitive stacks, and citicoline in focus, memory and neuro-support products. Combination concepts are common, and our technical team can advise on dose ranges, excipient compatibility and stability data for each finished format.
Format guidance is part of our supplier service. For capsules, crystalline powders such as NMN and NR HCL blend readily with standard excipients at inclusion levels of 1-10%; for stick-packs and effervescent tablets, we recommend the more water-soluble forms and can provide sieve fractions; for gummies and soft gels, sensory and stability input is available before scale-up. Regulatory agencies recognize these ingredients as suitable for dietary supplement use in many markets, and our documentation supports your own regulatory review.
Manufacturing & Quality Control
Quality control follows a documented system aligned with GMP principles and the requirements of ISO 9001 and FSSC 22000 certified management systems. Each batch is tested for identity by HPLC or GC against a reference standard, assay, related substances, residual solvents, heavy metals, microbial limits, loss on drying and particle size where applicable. Analytical methods follow current USP-NF and European Pharmacopoeia monographs where they exist, complemented by AOAC-based procedures.
Kosher and Halal certifications are available for designated products, and non-GMO and non-irradiation status is confirmed per batch on request. A full Certificate of Analysis is issued with every shipment, and retained samples are kept for traceability. Finished lots can be audited by customers under a confidentiality agreement.
New Products for B2B Supplement Manufacturing
Purecium is a bulk supplier to distributors, contract manufacturers, private-label producers and supplement brands worldwide, with more than 15 years of experience in nutraceutical ingredient export. For the New Products range we offer a standard MOQ of 25 kg per item, drum or bag packing with export-grade labeling, full COA and SDS documentation, and a lead time of 7-15 days for in-stock materials with global shipping arranged by sea, air or express.
Samples with specifications are provided for evaluation before bulk commitment, and regulatory documents such as flowcharts, allergen statements and stability summaries can be shared under NDA. Whether you are developing a NAD+ precursor product or adding spermidine to an existing longevity line, our sales and quality teams respond with documented answers rather than generic quotations.
Reviewed by the Chief Quality Assurance / Regulatory Affairs Specialist at Purecium for technical accuracy and regulatory alignment.
PURECIUM NEW PRODUCTS B2B FAQ
Q1: What is the difference between NMN and Nicotinamide Riboside (NR)?
A: Both are NAD+ precursors, but they differ in structure and uptake. NMN (CAS 1094-61-7) is the phosphorylated mononucleotide form, while NR (CAS 1341-23-7 as cation; chloride salt CAS 23111-00-4) is the unphosphorylated riboside. NR must be phosphorylated to NMN inside cells before conversion to NAD+. Many formulators use them interchangeably in anti-aging and cellular-energy products, and choice is usually driven by cost, stability and consumer recognition.
Q2: What purity and assay do you supply for NMN powder?
A: We supply NMN at 98% minimum assay by HPLC, with typical lots at 99%+. The specification covers related substances (nicotinamide, nicotinic acid), residual solvents, heavy metals, microbial limits and loss on drying, and each lot ships with a full Certificate of Analysis.
Q3: Is your NR HCL the same chemical as niacin or nicotinamide?
A: No. Niacin, nicotinamide and NR are all forms of vitamin B3, but NR is a pyridine-nucleoside form that enters the NAD+ salvage pathway more directly. Our NR HCL is the chloride salt with CAS 23111-00-4 and assay of 98% minimum by HPLC.
Q4: How is Urolithin A produced and is it vegan?
A: Urolithin A (CAS 1143-70-0) is produced by controlled microbial fermentation rather than by animal extraction, so it is fully vegan and non-GMO. The process yields a consistent 98% minimum assay, avoiding the batch variability of relying on gut-microbiota conversion in consumers.
Q5: What is the difference between Urolithin A and Urolithin B?
A: Urolithin A (C13H8O4, 228.20 g/mol) has an additional hydroxyl group compared with Urolithin B (C13H8O3, 212.20 g/mol). Urolithin A is the form most studied for mitophagy and muscle-health benefits; both can be supplied, and Urolithin A is the standard item in our catalog.
Q6: Do you supply Spermidine as a pure salt or as an extract?
A: Both options are available. Spermidine trihydrochloride is a pure crystalline form (CAS 124-20-9, C7H19N3, 145.25 g/mol, 98% assay) for precise dosing, and wheat-germ extract standardized to spermidine content is available for whole-food positioning. We recommend the salt for dose accuracy and the extract for label friendly botanical claims.
Q7: What is the source of your Fisetin?
A: Our fisetin (CAS 528-48-3) is extracted from natural plant sources such as strawberry and apple and purified to 98% minimum assay by HPLC. The specification includes identification by UV and HPLC retention time, heavy metals and microbial testing per batch.
Q8: Is Citicoline the same as CDP-Choline?
A: Yes. Citicoline and CDP-choline are the same molecule (CAS 987-78-0; C14H26N4O11P2). We supply both the free form and citicoline sodium, with assay of 98-102% and strict impurity control, for cognitive and memory supplement formulations.
Q9: What stability and storage requirements apply to these ingredients?
A: All six products are stable for 24 months from manufacture when stored sealed, below 25°C, protected from moisture and direct light. NMN and NR HCL are hygroscopic and must be kept in airtight drums; urolithin A and fisetin should be protected from strong light. Stability data under ICH conditions are available on request.
Q10: Are these ingredients compliant for use in dietary supplements?
A: The ingredients are manufactured to food-grade specifications suitable for dietary supplement use. Regulatory status varies by market - for example, novel food requirements in the EU are assessed under the EFSA novel food framework - so finished-product manufacturers should confirm current authorization, dosage limits and labeling rules for each target country before launch.
Q11: Do you provide documentation for customs and regulatory filing?
A: Yes. Every shipment includes the Certificate of Analysis, and we provide SDS, allergen and GMO statements, flowcharts, method summaries and specification documents. Origin certificates and export documentation are prepared for customs clearance, and our team supports document review for distributor registration.
Q12: What are the typical particle sizes and can you customize them?
A: Standard material passes through 80-100 mesh; crystalline items such as NMN and citicoline can be milled to finer particle sizes for tableting or beverage blending. Sieve analysis is reported on the COA, and custom mesh specifications can be agreed for production batches.
Q13: What is your minimum order quantity and lead time?
A: The standard MOQ is 25 kg per item for the New Products range. In-stock items ship within 7-15 days; production orders typically take 20-30 days depending on the product and specification. Global shipping is available by sea, air or express with tracking provided.
Q14: Can I get samples before placing a bulk order?
A: Yes. Free samples of 10-50 g with the current specification sheet are provided for evaluation. Sample requests are confirmed within one working day, and our technical team can advise on assay methods and stability if you plan to run your own qualification.
Q15: Are these ingredients sold to individual consumers?
A: No. Purecium operates strictly B2B and supplies bulk raw materials to registered businesses only - manufacturers, distributors, contract manufacturers and supplement brands. We do not sell to end consumers, and minimum order quantities are enforced to keep the supply chain professional.
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